Comparative effect of 5α‐dihydrotestosterone (DHT) and 17β‐estradiol (E2) on norepinephrine (NE)‐induced hypertrophy in neonatal rat ventricular myocytes (NRVM)
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منابع مشابه
Protein kinase C- -induced hypertrophy of neonatal rat ventricular myocytes
Vijayan, Kalpana, Erika L. Szotek, Jody L. Martin, and Allen M. Samarel. Protein kinase C-induced hypertrophy of neonatal rat ventricular myocytes. Am J Physiol Heart Circ Physiol 287: H2777– H2789, 2004. First published July 22, 2004; doi:10.1152/ajpheart. 00171.2004.—Protein kinase C (PKC) isoenzymes play a critical role in cardiomyocyte hypertrophy. At least three different phorbol estersens...
متن کاملEffects of stachydrine on norepinephrine-induced neonatal rat cardiac myocytes hypertrophy and intracellular calcium transients
BACKGROUND Leonurus heterophyllus sweet has been suggested to have cardioprotective effects against heart diseases, including ischemic diseases and ventricular remodeling. However, the active ingredients of the herb and the underlying mechanisms are poorly understood. The aim of the present study was to investigate the effects of stachydrine (STA), a major constituent of Leonurus heterophyllus ...
متن کاملSignaling responses after exposure to 5 -dihydrotestosterone or 17 -estradiol in norepinephrine-induced hypertrophy of neonatal rat ventricular myocytes
Koshman YE, Piano MR, Russell B, Schwertz DW. Signaling responses after exposure to 5 -dihydrotestosterone or 17 -estradiol in norepinephrine-induced hypertrophy of neonatal rat ventricular myocytes. J Appl Physiol 108: 686–696, 2010. First published December 31, 2009; doi:10.1152/japplphysiol.00994.2009.—Androgens appear to enhance, whereas estrogens mitigate, cardiac hypertrophy. However, sig...
متن کاملAldosterone increases NHE-1 expression and induces NHE-1-dependent hypertrophy in neonatal rat ventricular myocytes.
We determined the effect of 24-hour aldosterone (100 nmol/L) treatment on hypertrophic responses in rat neonatal ventricular myocytes and the possible role of Na+-H+ exchange isoform 1 (NHE-1). Aldosterone significantly increased cell size by 61% and expression of atrial natriuretic peptide by 2-fold. NHE-1 mRNA expression and protein abundance were significantly increased, and intracellular Na...
متن کاملRole of protein kinase C-e in hypertrophy of cultured neonatal rat ventricular myocytes
Strait, James B., III, Jody L. Martin, Allison Bayer, Ruben Mestril, Diane M. Eble, and Allen M. Samarel. Role of protein kinase C-e in hypertrophy of cultured neonatal rat ventricular myocytes. Am J Physiol Heart Circ Physiol 280: H756–H766, 2001.—Using adenovirus (Adv)-mediated overexpression of constitutively active (ca) and dominantnegative (dn) mutants, we examined whether protein kinase C...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2008
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.22.1_supplement.466.1